N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response

Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses.

N-linked glycosylation is a central regulatory factor that influences the immune system in varied and profound ways, including leukocyte homing, T cell receptor signaling and others. Moreover, N-glycan branching has been demonstrated to change as a function of infection and inflammation. Our previous findings suggest that complex-type N-glycans on the class II major histocompatibility complex p...

Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes.

The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence supporting a role for N-linked carbohydrate stems from the treatment of target cells with the glycosylation inhibitor tunicamycin (TM). In this report, we show that treatment of targets with TM, but not ...

تاثیر واکسن سلول‌های دندریتیک فعال شده با اجزاء پروتیینی توکسوپلاسما گوندی بر سلول‌های T از نوع CD8+ اختصاصی تومور

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Deficiency of C5aR prolongs renal allograft survival.

Interaction between C5a, a product of complement activation, and its receptor (C5aR) upregulates antigen-specific T cell responses by modulating the activation of antigen-presenting cells and T cells. Whether this C5a-C5aR interaction contributes to the immune responses that promote renal allograft rejection is unknown. Here, we found that deficiency of C5aR in both graft and recipient reduced ...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.